About Us

Where we stand

neuronal microtubulesMAPREG ambition is to rescue damaged neuronal function by stimulating the microtubules: a groundbreaking biological approach.

Microtubules form an intracellular network ensuring vital transport of various molecules throughout cells. In the Central Nervous System, alterations in microtubules, including changes in their composition, function and excitotoxic-induced degradation, are at the heart of the main pathophysiological phenomena associated with traumatic injuries, psychiatric disorders, neurodegenerative diseases and stroke.

MAPREG concept consists in stimulating MAP2 with highly specific drug candidates, derived from PREG, to protect and/or regenerate altered neuronal microtubules, thus enabling the neurons to preserve or to recover their architecture, to function and work together. This mechanism has been proven pivotal yet unexplored for a healthy neuronal function.

MAPREG applies this innovative medical strategy for treating several neuronal pathologies:

MAP4343, our lead drug candidate, is proved safe in human beings (successful human Phase 1). Preclinical Animal studies ascertain robust neuro-protective, neuro-regenerative and anti-depressive properties. Tubulin modifications is a biomarker of its action.

Today

CHU Bicêtre, Batiment Pincus, 80 rue du général Leclerc, 94270 Le Kremlin-Bicêtre, France.