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Stimulating microtubules dynamics to rescue neuronal function
Alterations in microtubules, including changes in their composition, function and excitotoxic-induced degradation, are at the heart of the main pathophysiological phenomena associated with traumatic injuries, psychiatric disorders, neurodegenerative diseases and stroke.
MAPREG’s team has identified the protein MAP2 (Microtubule-Associated-Protein 2) as the specific functional receptor of Pregnenolone (PREG) in the CNS : PREG binds to MAP2 and promotes microtubules polymerization and neurite outgrowth.
MAPREG develops PREG-derivatives, non hormonal compounds, that reach the CNS and target MAP2, and that stimulate, protect and repair altered neuronal microtubules
CHU Bicêtre, Batiment Pincus,
80 rue du général Leclerc, 94270 Le Kremlin-Bicêtre, France.